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Subjects who weighed more and were healthier - and were therefore more like athletes who use the drugs, observes Grunfeld - required higher doses to gain weight. Already after 6-8 weeks of use of methandrostenolone, as even a single drug of the cycle, the user may secure the increase from 6 to 10kg. However, the action of methandrosternolone was limited to slow-contracting muscles, while 20-Hydroxyecdysone produced anabolic effects in various types of skeletal muscles. Whether an individual using AAS will develop any of these side effects is difficult to predict because of the complex interaction between factors like drug type, dosage, duration of use, and individual (genetic) differences.

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